The earliest reference to Sopwell House is found in a deed of 1603, which makes reference to the house as the newly built 'New Barnes' Home to Richard Sadlier. Little is known about the intervening period until 1665 when the Duchess Alice/Alicia, a member of the illustrious Dudley family, took up residence during the great plague and fire of London. The name New Barnes is still in use locally today with 'New Barnes Mill' and its bridge situated nearby.
In 1670 the house was bought by Sir Harbottle Grimston, Earl of Verulam, owner of the Gorhambury estate. Gorhambury was built by Sir Richard Lee on the ruins of the Sopwell Nunnery which became the possession of Francis Bacon, the 1st Baron of Verulam. The Sopwell Nunnery is believed to have been where Anne Boleyn took refuge following her return from France and where her secret marriage to King Henry VIII took place.
At the beginning of the 18th Century, Edward Strong, a Master Mason known to have worked on St. Paul's Cathedral, leased the house and it is assumed that he developed the house further during his tenure.
Admiral of the Fleet, Prince Louis of Battenberg, Father of Louis and Alice, leased the house as his family's country home in 1901. Louis, later Lord Mountbatten of Burma, was the last Governor of India. Alice married Prince Andrew of Greece and was the mother of Prince Phillip Duke of Edinburgh. It is believed that Prince Andrew proposed to Alice in the gardens of Sopwell House.
As part of the Verulam estate, Sopwell House was used by members of the family until the end of the Second World War when it became a home for the aged before its conversion in 1969 to a hotel. The present owner, Abraham Bejerano, purchased the property in 1986 and has sensitively developed and updated the facilities taking immense care to retain the character and charm of the original Georgian house.